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Fig. 5 | Mobile DNA

Fig. 5

From: Pan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity

Fig. 5

Analysis of methylation and copy number variation of L1 ASP-associated genes. Aย The expression of top 20 L1 ASP-associated genes in various cancers. Bย The functional enrichment analysis suggested that top 20 L1 ASP-associated genes were involved in the classical cancer pathways such as the P53 signaling pathway. Cย The methylation levels of top 20 L1 ASP-associated genes. Blue represents hypomethylation of the promoter region of the relevant gene, and red represents hypermethylation of the promoter region of the relevant gene. Dย The protein interaction network study of the top 20 genes using the STRING database suggested that MCM2 and CENPU were the key genes (hub genes) among them. E Fย The mutation and copy number variation profiles of SPP1 and MCM2 at the pan-cancer level

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ISSN: 1759-8753