Fig. 4

The VNTR and 5′ hexameric repeats determine mobilization capacity of human SVA. a VNTR structure of the H8_43 deletion mutants. VNTR subunits are encoded as in Lupan et al. [4]. Subunit arrays are bracketed. The VNTR subunit structure of H19_27 is given for comparison. TR – Tandem Repeat, fixed 5′ part of the domain; VNTR – variable length central part of the domain. b „In-frame“-deletions in the VNTR reduce SVA mobilization rates up to 90%. c Deletion of both the central part of the VNTR and the 5′ hexameric repeats has an additive effect. Retrotransposition rates +/− SEM are shown relative to the full-length element (100%). n = 3 for each independent set of experiments