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Fig. 1 | Mobile DNA

Fig. 1

From: Deep sequencing reveals new roles for MuB in transposition immunity and target-capture, and redefines the insular Ter region of E. coli

Fig. 1

Mu transposition and target immunity. a. The transposase MuA pairs Mu ends and introduces single-strand nicks, joining these to MuB-captured target DNA (red arrows). MuB binds DNA non-specifically, polymerizing in short filaments, and increases the catalytic efficiency of target capture. b. Cis-immunity and Mu genome immunity. Cis-immunity is characterized by the lack of insertions outside Mu ends (typically within 5 kb), and Mu genome immunity by absence of insertion anywhere within the ~ 37 kb Mu genome

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